报告题目：3D printing of drug eluting devices: from prototyping to personalized medicine
主讲人：Prof. Jean-Christophe Leroux
主持人：刘密 教授
时间：2024年12月10日 10:00-11:00
地点：云轩楼2108会议室
专家简介
Jean-Christophe Leroux博士是苏黎世瑞士联邦理工学院（ETH Zurich）MK·体育,MK(中国)药物制剂和药物递送专业的正教授，三家ETH Zurich孵化的生物制药公司（Obaris AG、Versantis AG和Inositec AG）的联合创始人。Leroux教授既有很高的学术成就，也对生物医药转化和产业化应用有很大的贡献。Leroux教授在蒙特利尔大学（加拿大）获得药学学士学位，在日内瓦大学（瑞士）获得药学博士学位，曾在加州大学旧金山分校（美国）从事博士后研究。Leroux博士于1997年至2008年担任蒙特利尔大学制药技术教授。他在生物材料和药物递送领域基础研究和应用研究领域做出了重要贡献，参与了创新生物解毒系统的开发。他是AAPS、EURASC、法国药学会和CRS等的会员。
内容简介
Three-dimensional (3D) printing is a potent method for creating affordable, personalized medical devices on demand (1). Among various 3D printing techniques, digital light processing (DLP) is notable for its fast fabrication of high-resolution objects. However, the production of bioresorbable medical devices using DLP is currently limited by the absence of appropriate biomedical inks. Here, we developed novel polyester-based inks that allow for DLP printing of therapeutic devices with tunable mechanical properties and degradation profiles. The most promising materials were used to design biodegradable customized airway stents. These stents degraded to soft innocuous hydrogels in vitro and disappeared 7 weeks after insertion in rabbits (2). The 3D printed stents could be loaded with drugs such as levofloxacin or nintedanib whose release kinetics could be adjusted by varying the copolymer composition. In addition, shape memory temperature-responsive stents were also 3D printed (3). By tuning the glass transition temperature of the polymeric matrix, it was possible to engineer folded stents that could be easily deployed at body temperature. Lastly, DLP was used as prototyping method to fabricate and optimize various oral formulations. Buccal suction patches mimicking the suction cup of octopuses were investigated for the administration of peptidic drugs (4) while pH-sensitive colonic capsules capable of encapsulating aqueous suspensions were investigated for the delivery of live probiotics (5). These studies open new perspectives for the rapid manufacturing of complex devices with superior properties.
Funding from SNSF (Sinergia CRSII5_177178 and 315230_197644) and ETH (Research grant 33-20-1) is acknowledged.
References
1) Liang K et al., Adv. Mater. 2019, 31, 1805680.
2) Paunovic N et al., Sci Adv 2021, 7, eabe9499.
3) Paunovic N et al. J Control Release 2023, 361, 417-426.
4) Luo Z et al., Sci Transl Med 2023, 15, eabq1887.
5) Green Buzhor M, et al. Adv Mater Technol 2024, 9:2301975.
